4-chloro-1H-pyrazolo[3,4-b]pyridin-3-amine
4-chloro-1H-pyrazolo[3,4-b]pyridin-3-amine
CAS: 1211520-57-8
Molecular Formula: C6H5ClN4
4-chloro-1H-pyrazolo[3,4-b]pyridin-3-amine - Names and Identifiers
| Name | 4-chloro-1H-pyrazolo[3,4-b]pyridin-3-amine |
| Synonyms | 4-chloro-1H-pyrazolo[3,4-b]pyridin-3-aMine 4-chloro-1H-pyrazolo[3,4-b]pyridin-3-amine |
| CAS | 1211520-57-8 |
4-chloro-1H-pyrazolo[3,4-b]pyridin-3-amine - Physico-chemical Properties
| Molecular Formula | C6H5ClN4 |
| Molar Mass | 168.58 |
4-chloro-1H-pyrazolo[3,4-b]pyridin-3-amine - Introduction
4-Chloro-1H-pyrazolo [3,4-b] pyridin -3-amine is an organic compound whose chemical formula is C11H7ClN4. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-Chloro-1H-pyrazolo [3,4-b] pyridin -3-amine is a white or light yellow solid.
-Melting point: about 200-205 degrees Celsius.
-Solubility: Good solubility in common organic solvents, such as ethanol, dimethyl sulfoxide and dichloromethane.
-Stability: High stability, generally not easy to decompose under conventional experimental conditions.
Use:
-Antitumor Activity: 4-Chloro-1H-pyrazolo [3,4-b] pyridin -3-amine is a compound with potential antitumor activity. It can exert anti-tumor effects by inhibiting cell proliferation and inducing apoptosis.
-Chemical research: Due to its unique structure, 4-chloro-1H-pyrazolo [3,4-b] pyridine-3-amine can also be used in the study of organic synthesis and is used as some organic chemical reagents Intermediate.
Preparation Method:
There are many ways to prepare 4-chloro-1H-pyrazolo [3,4-b] pyridine-3-amine. The following is a common synthetic route:
1. First, 4-chloroaminopyrrole is hydrogenated in N-methylpyrrolidone using indium chloride as a catalyst to obtain 4-chloro-1H-pyrrolo [3,4-b] pyridine.
2. Then, react with ammonia gas to convert the dehydroamino group of 4-chloroaminopyrrole into an amino group to obtain 4-amino-1H-pyrrolo [3,4-b] pyridine.
3. Finally, 4-amino-1H-pyrrolo [3,4-b] pyridine is reacted with hydrogen chloride to generate the target product 4-chloro-1H-pyrazolo [3,4-b] pyridin -3-amine.
Safety Information:
-4-Chloro-1H-pyrazolo [3,4-b] pyridin -3-amine is an organic compound, which may be irritating and dangerous to the human body.
-When using and handling this compound, strict personal protective measures should be observed, such as wearing protective glasses, gloves and protective clothing.
-When performing experimental operations, it should be carried out in a well-ventilated laboratory to avoid inhaling its vapor or touching its skin.
-If you ingest or come into contact with the compound, you should seek medical attention immediately and provide the compound's safety data sheet for reference.
In addition, proper laboratory procedures and safe handling guidelines should generally be followed when handling compounds in the laboratory.
Nature:
-Appearance: 4-Chloro-1H-pyrazolo [3,4-b] pyridin -3-amine is a white or light yellow solid.
-Melting point: about 200-205 degrees Celsius.
-Solubility: Good solubility in common organic solvents, such as ethanol, dimethyl sulfoxide and dichloromethane.
-Stability: High stability, generally not easy to decompose under conventional experimental conditions.
Use:
-Antitumor Activity: 4-Chloro-1H-pyrazolo [3,4-b] pyridin -3-amine is a compound with potential antitumor activity. It can exert anti-tumor effects by inhibiting cell proliferation and inducing apoptosis.
-Chemical research: Due to its unique structure, 4-chloro-1H-pyrazolo [3,4-b] pyridine-3-amine can also be used in the study of organic synthesis and is used as some organic chemical reagents Intermediate.
Preparation Method:
There are many ways to prepare 4-chloro-1H-pyrazolo [3,4-b] pyridine-3-amine. The following is a common synthetic route:
1. First, 4-chloroaminopyrrole is hydrogenated in N-methylpyrrolidone using indium chloride as a catalyst to obtain 4-chloro-1H-pyrrolo [3,4-b] pyridine.
2. Then, react with ammonia gas to convert the dehydroamino group of 4-chloroaminopyrrole into an amino group to obtain 4-amino-1H-pyrrolo [3,4-b] pyridine.
3. Finally, 4-amino-1H-pyrrolo [3,4-b] pyridine is reacted with hydrogen chloride to generate the target product 4-chloro-1H-pyrazolo [3,4-b] pyridin -3-amine.
Safety Information:
-4-Chloro-1H-pyrazolo [3,4-b] pyridin -3-amine is an organic compound, which may be irritating and dangerous to the human body.
-When using and handling this compound, strict personal protective measures should be observed, such as wearing protective glasses, gloves and protective clothing.
-When performing experimental operations, it should be carried out in a well-ventilated laboratory to avoid inhaling its vapor or touching its skin.
-If you ingest or come into contact with the compound, you should seek medical attention immediately and provide the compound's safety data sheet for reference.
In addition, proper laboratory procedures and safe handling guidelines should generally be followed when handling compounds in the laboratory.
Last Update：2024-04-10 22:29:15
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